The San Francisco 49ers (2-6 SU, 2-6 ATS, 4-3-1 O/U) and Arizona Cardinals (5-3 SU, 6-2 ATS, 5-3 O/U) are headed in opposite directions as they take the field for this Monday night matchup at University of Phoenix Stadium.

Arizona Cardinals
While the high-scoring Cardinals have won five straight games and are coming off a solid victory in their last game, the 49ers enter this divisional showdown riding a convincing five-game losing streak with no end in sight.
The Cardinals beat the St. Louis Rams 34-13 on Sunday as quarterback Kurt Warner completed 23 of 34 passes for 342 yards and two touchdowns and explosive running back Tim Hightower added 109 yard and one touchdown on 22 carries.
Ironically, the 49ers lost to the lowly Seattle Seahawks by the exact same score, 34-13 on Oct. 26 and enter this contest well-rested after getting a bye in Week 9.
Former starting quarterback J.T. O’Sullivan passed for 131 yards with an interception for San Francisco while running back Frank Gore rushed for 94 yards on 18 carries. O’Sullivan will be replaced by backup Shaun Hill for this contest after interim head coach Mike Singletary benched O’Sullivan for the second half of their matchup with Seattle.
Hill completed 15 of 23 passes for 173 yards with one touchdown and no interceptions.
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